EXOC6 Antibody

產(chǎn)品詳情

Uniprot No.：

Q8TAG9
基因名：

EXOC6
別名：

EXOC6 antibody; SEC15A antibody; SEC15L antibody; SEC15L1 antibody; Exocyst complex component 6 antibody; Exocyst complex component Sec15A antibody; SEC15-like protein 1 antibody
宿主：

Rabbit
反應(yīng)種屬：

Human,Mouse,Rat
免疫原：

Human EXOC6
免疫原種屬：

Homo sapiens (Human)
抗體亞型：

IgG
純化方式：

Antigen Affinity Purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA,WB
Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
儲(chǔ)存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. Together with RAB11A, RAB3IP, RAB8A, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis.
基因功能參考文獻(xiàn)：
1. NDR2-mediated Rabin8 phosphorylation is crucial for ciliogenesis by triggering the switch in binding specificity of Rabin8 from PS to Sec15. PMID: 23435566
2. coordinated disruption of the Rab11/Sec15 exocyst by anthrax toxins may contribute to toxin-dependent barrier disruption and vascular dysfunction during B. anthracis infection PMID: 20944747
3. Sec15 has a role as an effector for the Rab11 GTPase in mammalian cells PMID: 15292201
4. The SEC15 protein plays a crucial role in integrating the signals between Sec4p and the components of the early-polarity-establishment machinery. PMID: 16478783
亞細(xì)胞定位：

Cytoplasm. Cytoplasm, perinuclear region. Cell projection, growth cone. Midbody, Midbody ring.
蛋白家族：

SEC15 family
數(shù)據(jù)庫鏈接：

HGNC: 23196

OMIM: 609672

KEGG: hsa:54536

STRING: 9606.ENSP00000260762

UniGene: Hs.655657