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  4. ELMO2 Antibody

ELMO2 Antibody

  • 中文名稱：
    ELMO2兔多克隆抗體
  • 貨號(hào)：
    CSB-PA007612GA01HU
  • 規(guī)格：
    ￥3,900
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    ELMO2
  • 別名：
    CED 12 antibody; Ced 12 homolog 2 antibody; CED 12 homolog A antibody; CED 12A antibody; CED-12 antibody; ced-12 homolog 2 antibody; CED12 antibody; CED12 homolog A antibody; CED12; C. elegans; homolog of; 2 antibody; CED12A antibody; ELMO 2 antibody; ELMO-2 antibody; ELMO2 antibody; ELMO2_HUMAN antibody; Engulfment and cell motility 2 (ced 12 homolog; C. elegans) antibody; Engulfment and cell motility 2 antibody; Engulfment and cell motility gene 2 antibody; Engulfment and cell motility protein 2 antibody; FLJ11656 antibody; hCED 12A antibody; hCED-12A antibody; hCED12A antibody; KIAA1834 antibody; OTTHUMP00000031762 antibody; PH domain protein CED12A antibody; Protein ced 12 homolog A antibody; Protein ced-12 homolog A antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse,Rat
  • 免疫原：
    Human ELMO2
  • 免疫原種屬：
    Homo sapiens (Human)
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,IHC
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1.
  • 基因功能參考文獻(xiàn)：
    1. These data suggest a novel link between Tiam1 and RhoG/ILK /ELMO2 pathway as upstream effectors of the Rac1-mediated phagocytic process in trabecular meshwork cells. PMID: 27539661
    2. studies demonstrate that Elmo2 is a new regulator of insulin-dependent Glut4 membrane translocation through modulating Rac1 activity and Akt membrane compartmentalization. PMID: 27226625
    3. findings highlight the necessity of ELMO2 for maintaining vascular integrity, specifically in intramembranous bones; loss-of-function mutations in ELMO2 cause intraosseous vascular malformation by impeding RAC1 signaling PMID: 27476657
    4. Axl has a role in phosphorylating the Elmo scaffold proteins to promote Rac activation and cell invasion PMID: 25332238
    5. uncovered a role for ELMO in the recruitment of ACF7 to the membrane to promote microtubule capture and stability PMID: 23184944
    6. Through its association with ELMO2, ILK plays key roles in the regulation of Rho GTPases and cross-talk pathways between adhesion and growth factor receptors. PMID: 22568984

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  • 相關(guān)疾病：
    Vascular malformation, primary intraosseous (VMOS)
  • 亞細(xì)胞定位：
    Cytoplasm. Cytoplasm, cytosol. Membrane.
  • 組織特異性：
    Widely expressed, with a higher expression in skeletal muscle, kidney and placenta.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 17233

    OMIM: 606421

    KEGG: hsa:63916

    STRING: 9606.ENSP00000290246

    UniGene: Hs.210469



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