EDC4 Antibody

說(shuō)明書(shū)

產(chǎn)品詳情

Uniprot No.：

Q6P2E9
基因名：

EDC4
別名：

autoantigen antibody; Autoantigen Ge 1 antibody; Autoantigen Ge-1 antibody; Autoantigen Ge1 antibody; Autoantigen RCD 8 antibody; Autoantigen RCD-8 antibody; Autoantigen RCD8 antibody; edc4 antibody; EDC4_HUMAN antibody; Enhancer of mRNA decapping 4 antibody; Enhancer of mRNA-decapping protein 4 antibody; Ge 1 antibody; Hedls antibody; Human enhancer of decapping large subunit antibody; RCD 8 antibody
宿主：

Rabbit
反應(yīng)種屬：

Human,Mouse,Rat
免疫原：

Human EDC4
免疫原種屬：

Homo sapiens (Human)
抗體亞型：

IgG
純化方式：

Antigen Affinity purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA,WB
Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
儲(chǔ)存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

In the process of mRNA degradation, seems to play a role in mRNA decapping. Component of a complex containing DCP2 and DCP1A which functions in decapping of ARE-containing mRNAs. Promotes complex formation between DCP1A and DCP2. Enhances the catalytic activity of DCP2 (in vitro).
基因功能參考文獻(xiàn)：
1. EDC4 plays a key role in homologous recombination by stimulating end resection at double-strand breaks. PMID: 29511213
2. The assembly of EDC4 and Dcp1a into processing bodies is critical for the translational regulation of IL-6. PMID: 25970328
3. EDC4 is a processing body (P-body) component. PMID: 24858563
4. The data indicates that DCP2 activation by DCP1 occurs preferentially on the EDC4 scaffold, which may serve to couple DCP2 activation by DCP1 with 5'-to-3' mRNA degradation by XRN1 in human cells. PMID: 24510189
5. EDC4 might contribute to regulation of CoA biosynthesis in addition to its scaffold function in processing bodies PMID: 22982864
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亞細(xì)胞定位：

Cytoplasm, P-body. Nucleus.
蛋白家族：

WD repeat EDC4 family
數(shù)據(jù)庫(kù)鏈接：

HGNC: 17157

OMIM: 606030

KEGG: hsa:23644

STRING: 9606.ENSP00000351811

UniGene: Hs.75682