ARFIP1 Antibody

說(shuō)明書

產(chǎn)品詳情

Uniprot No.：

P53367
基因名：

ARFIP1
別名：

ADP ribosylation factor interacting protein 1 antibody; ADP-ribosylation factor-interacting protein 1 antibody; Arfaptin antibody; Arfaptin-1 antibody; ARFIP 1 antibody; Arfip1 antibody; ARFP1_HUMAN antibody; HSU52521 antibody; MGC117369 antibody
宿主：

Rabbit
反應(yīng)種屬：

Human,Mouse,Rat
免疫原：

Human ARFIP1
免疫原種屬：

Homo sapiens (Human)
抗體亞型：

IgG
純化方式：

Antigen Affinity purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA,WB,IHC,IF
Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
儲(chǔ)存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Plays a role in controlling biogenesis of secretory granules at the trans-Golgi network. Mechanisitically, binds ARF-GTP at the neck of a growing secretory granule precursor and forms a protective scaffold. Once the granule precursor has been completely loaded, active PRKD1 phosphorylates ARFIP1 and releases it from ARFs. In turn, ARFs induce fission. Through this mechanism, ensures proper secretory granule formation at the Golgi of pancreatic beta cells.
基因功能參考文獻(xiàn)：
1. inhibits ADP-ribosylation factor-dependent matrix metalloproteinase-9 secretion induced by phorbol ester in fibrosarcoma cells PMID: 12606037
亞細(xì)胞定位：

Golgi apparatus. Golgi apparatus, trans-Golgi network membrane.
組織特異性：

Ubiquitously expressed. Higher levels in liver, pancreas, placenta, skeletal muscle and heart.
數(shù)據(jù)庫(kù)鏈接：

HGNC: 21496

OMIM: 605928

KEGG: hsa:27236

STRING: 9606.ENSP00000296557

UniGene: Hs.416089