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中文名稱：
AGBL4兔多克隆抗體
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貨號(hào)：
CSB-PA598753
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規(guī)格：
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圖片：
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其他：
產(chǎn)品詳情
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產(chǎn)品名稱：
Rabbit anti-Homo sapiens (Human) AGBL4 Polyclonal antibody
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Uniprot No.：
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基因名：
AGBL4
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宿主：
Rabbit
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反應(yīng)種屬：
Human
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免疫原：
Synthesized peptide derived from internal of Human CBCP6.
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免疫原種屬：
Homo sapiens (Human)
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克隆類型：
Polyclonal
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純化方式：
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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濃度：
It differs from different batches. Please contact us to confirm it.
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產(chǎn)品提供形式：
Liquid
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應(yīng)用范圍：
ELISA,WB
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推薦稀釋比：
| Application |
Recommended Dilution |
| WB |
1:500-1:3000 |
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Protocols：
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儲(chǔ)存條件：
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：
For Research Use Only. Not for use in diagnostic or therapeutic procedures.
靶點(diǎn)詳情
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功能：
Metallocarboxypeptidase that mediates protein deglutamylation of tubulin and non-tubulin target proteins. Catalyzes the removal of polyglutamate side chains present on the gamma-carboxyl group of glutamate residues within the C-terminal tail of tubulin protein. Specifically cleaves tubulin long-side-chains, while it is not able to remove the branching point glutamate. Also catalyzes the removal of polyglutamate residues from the carboxy-terminus of non-tubulin proteins such as MYLK. Mediates the deglutamylation of nucleotidyltransferase CGAS, leading to CGAS antiviral defense response activation. Involved in KLF4 deglutamylation which promotes KLF4 proteasome-mediated degradation, thereby negatively regulating cell pluripotency maintenance and embryogenesis.
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基因功能參考文獻(xiàn)：
- ABGL4, LRP8 and PCSK9 polymorphisms and gene interactions increase cardiometabolic risk. PMID: 27853278
- AGBL4 promoter hypermethylation is associated with Colorectal Cancer. PMID: 25472652
- Nna1 and CCP4 remove the C-terminal glutamate from substrates with two or more glutamates, whereas CCP6 requires four or more glutamates. CCP4 behaves as a promiscuous glutamase with little preference for chain length or neighboring amino acid composition PMID: 25416787
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亞細(xì)胞定位：
Cytoplasm, cytosol. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Golgi apparatus. Cytoplasm, cytoskeleton, cilium basal body.
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蛋白家族：
Peptidase M14 family
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數(shù)據(jù)庫鏈接：
Most popular with customers
Western blot analysis of extracts from HeLa cells, Jurkat cells and A549 cells, using CBCP6 antibody.
