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  4. RNH1 Monoclonal Antibody

RNH1 Monoclonal Antibody

  • 中文名稱：
    RNH1 Monoclonal Antibody
  • 貨號：
    CSB-MA980298
  • 規(guī)格：
    ￥1320
  • 圖片：
    • Western blotting analysis using RNH1 antibody. Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with RNH1 antibody and HRP-conjugated goat anti-mouse secondary antibody respectively.
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Mouse anti-Homo sapiens (Human) RNH1 Monoclonal antibody
  • Uniprot No.：
  • 基因名：
    RNH1
  • 別名：
    RNH1; Ribonuclease/Angiogenin Inhibitor 1; RAI; RNH; Placental Ribonuclease Inhibitor; Placental RNase Inhibitor; Ribonuclease Inhibitor; Ribonuclease/Angiogenin Inhibitor; Testicular Tissue Protein Li 164; IIAE12; PRI
  • 宿主：
    Mouse
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human RNH1 protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    Mouse IgG1
  • 純化方式：
    Affinity-chromatography
  • 克隆號：
    22B12
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS (pH 7.4) containing 50% glycerol, and 0.02% sodium azide.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, WB
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2500
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Ribonuclease inhibitor which inhibits RNASE1, RNASE2 and ANG. May play a role in redox homeostasis.
  • 基因功能參考文獻(xiàn)：
    1. Results show that a low expression of RNH1 in metastasis of bladder cancer and suggest that it might regulate the function of ILK through mutual binding. PMID: 27576342
    2. a novel mechanism of ANG in regulating PI3K/AKT/mTOR signaling pathway via RI, is reported. PMID: 25193113
    3. RNH1 bound to RNase 7 and suppressed its antimicrobial activity by blocking its ability to bind the cell wall of uropathogenic bacteria. PMID: 24107847
    4. angiogenin and ILK signaling pathway plays a pivotal role in mediating the inhibitory effects of RI on melanoma cells growth PMID: 24769129
    5. RI could play a novel role in inhibiting metastasis of bladder cancer through regulating EMT and ILK signaling pathways. PMID: 24768914
    6. RNH1 as a regulator of HDACi resistance in gastric cancer PMID: 23584480
    7. RI might play a novel role in the development of bladder cancer through regulating EMT and the ILK signaling pathway. PMID: 23703635
    8. the anti-tumor effect of RNH1 is also involved in suppressing growth and metastasis PMID: 21125316
    9. RNH1 (as a recombinant fusion protein) is localized to mitochondria, nuclei, and cytosol in HeLa and HCT cells; RNH1 appears to bind to various mitochondrial proteins. PMID: 21276451
    10. Human ribonuclease inhibitor gene has antiangiogenic and antitumor effects when expressed in hematopoietic cells in mouse melanoma models. PMID: 15592448
    11. The conformational and oxidative stabilities of both RIs increase upon complex formation with ribonucleases. Thus, RI has evolved to maintain its inhibition of invading ribonucleases, even when confronted with extreme environmental stress. PMID: 17956129
    12. This the first measurement of the inhibition of the ribonucleolytic activity of onconase by ribonuclease inhibitor protein. PMID: 18930025

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  • 亞細(xì)胞定位：
    Cytoplasm.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 10074

    OMIM: 173320

    KEGG: hsa:6050

    STRING: 9606.ENSP00000346402

    UniGene: Hs.530687



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