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  4. CAPZA1 Monoclonal Antibody

CAPZA1 Monoclonal Antibody

  • 中文名稱：
    CAPZA1 Monoclonal Antibody
  • 貨號：
    CSB-MA242067
  • 規(guī)格：
    ￥1320
  • 圖片：
    • Flow cytometric analysis of CAPZA1 expression in C2C12 cells using CAPZA1 antibody. Green, isotype control; red, CAPZA1.
    • Western blotting analysis using CAPZA1 antibody. Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with CAPZA1 antibody and HRP-conjugated goat mouse secondary antibody respectively.
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Mouse anti-Homo sapiens (Human) CAPZA1 Monoclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    CAPZA1; Capping Actin Protein Of Muscle Z-Line Subunit Alpha 1; CAPPA1; Capping Protein (Actin Filament) Muscle Z-Line, Alpha 1; Capping Actin Protein Of Muscle Z-Line Alpha Subunit 1; F-Actin-Capping Protein Subunit Alpha-1; CapZ Alpha-1; Cap Z; CAPZ; CAZ1
  • 宿主：
    Mouse
  • 反應(yīng)種屬：
    Human, Mouse, Rat
  • 免疫原：
    Recombinant Human CAPZA1 protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    Mouse IgG1
  • 純化方式：
    Affinity-chromatography
  • 克隆號：
    11B6
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS (pH 7.4) containing 50% glycerol, and 0.02% sodium azide.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, WB, FC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:200-1:1000
    FC 1:100-1:1000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 功能：
    F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. May play a role in the formation of epithelial cell junctions.
  • 基因功能參考文獻(xiàn)：
    1. Data show that CAPZA1 inhibits EMT in hepatocellular carcinoma (HCC cells by regulating actin cytoskeleton remodeling, thereby reducing the metastatic ability of the cells. PMID: 28093067
    2. Disease causing mutations in inverted formin 2 regulate its binding to G-actin, F-actin capping protein (CapZ alpha-1) and profilin 2. PMID: 26764407
    3. mDia1 displaced from the barbed end by CapZ Actin Capping Protein can randomly slide along the actin filament and later return. PMID: 26566078
    4. The present study suggests that CAPZA1 could be a marker of good prognosis in gastric cancer and shows that CAPZA1 is associated with decreased cancer cell migration and invasion. PMID: 23545944
    5. CAPAZA1 is over expressed in malignant melanoma. PMID: 21566537
    6. V-1, a protein expressed transiently during murine cerebellar development, regulates actin polymerization via interaction with capping protein PMID: 12488317
    7. Cd2 antigen is linked to this protein via CMS and CIN85. PMID: 12690097
    8. CKIP-1 has a role in cell morphology that depends on its interaction with actin-capping protein PMID: 16987810
    9. Damaging exercise induced the expression of capZalpha, MCIP1, CARP1, DNAJB2, c-myc, and junD, each of which are likely involved in skeletal muscle growth, remodeling, and stress management. PMID: 18321953

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  • 亞細(xì)胞定位：
    Cytoplasm, cytoskeleton.
  • 蛋白家族：
    F-actin-capping protein alpha subunit family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 1488

    OMIM: 601580

    KEGG: hsa:829

    STRING: 9606.ENSP00000263168

    UniGene: Hs.744974



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