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  4. Mouse BMP-binding endothelial regulator protein(BMPER) ELISA kit

Mouse BMP-binding endothelial regulator protein(BMPER) ELISA kit

  • 中文名稱：
    小鼠BMP結(jié)合內(nèi)皮調(diào)節(jié)因子(BMPER)酶聯(lián)免疫試劑盒
  • 貨號：
    CSB-EL002747MO
  • 樣本類型：
    serum, plasma, tissue homogenates, cell lysates
  • 檢測范圍：
    31.25 pg/mL-2000 pg/mL
  • 靈敏度：
    7.81 pg/mL
  • 規(guī)格：
    96T/48T
  • 價格：
    ￥3600/￥2500
  • 促銷：
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    小鼠BMP結(jié)合內(nèi)皮調(diào)節(jié)因子(BMPER)酶聯(lián)免疫試劑盒（CSB-EL002747MO）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織勻漿、細胞裂解物樣本中的BMPER含量。BMPER是一個靶點。其它在相關(guān)生理過程中可能發(fā)揮一定作用。研究機制上，或許參與調(diào)控骨形態(tài)發(fā)生蛋白信號通路等，影響細胞的生長、分化等過程，但目前關(guān)于它的詳細研究機制還需進一步深入探索以明確其具體作用。試劑盒檢測范圍為31.25 pg/mL-2000 pg/mL，廣泛應(yīng)用于基礎(chǔ)科研領(lǐng)域，例如通過檢測疾病模型動物（如血管異?；蚱鞴侔l(fā)育缺陷模型）中BMPER的表達動態(tài)，探索其在病理生理中的作用機制，或用于體外細胞實驗中蛋白表達水平的定量評估，為信號通路研究、藥物靶點篩選及分子互作分析提供可靠工具。本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
  • 別名：
    Bmper ELISA kit; Cv2BMP-binding endothelial regulator protein ELISA kit; Bone morphogenetic protein-binding endothelial cell precursor-derived regulator ELISA kit; Protein crossveinless-2 ELISA kit; mCV2 ELISA kit
  • 縮寫：
    BMPER
  • Uniprot No.：
  • 種屬：
    Mus musculus (Mouse)
  • 反應(yīng)時間：
    1-5h
  • 上樣量：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領(lǐng)域：
    Cardiovascular
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產(chǎn)品評價

靶點詳情

  • 功能：
    Inhibitor of bone morphogenetic protein (BMP) function, it may regulate BMP responsiveness of osteoblasts and chondrocytes.
  • 基因功能參考文獻：
    1. BMPER contributes to the precise control of BMP activity within the aorta-gonad-mesonephros region, enabling the maturation of hematopoietic stem cells within a BMP-negative environment. PMID: 29093060
    2. CV2 binds directly to BMP10, as determined by co-immunoprecipitation, and inhibits BMP10 from initiating SMAD signaling, as determined by luciferase reporter gene assays. BMP10 and CV2 have important roles in coordinating cardiomyogenesis in progenitor cells. PMID: 28464239
    3. BMPER/low-density lipoprotein receptor-related protein 1 axis plays a pivotal role in pulmonary inflammatory response. PMID: 28596374
    4. The proangiogenic BMPER effect in endothelial cells is mediated by inhibition of antiangiogenic thrombospondin-1 and enhanced expression and activation of the FGF signaling pathway that is crucial in the promotion of angiogenesis. PMID: 25503991
    5. BMPER-induced BMP signaling promotes coronary artery remodeling. PMID: 24373957
    6. BMPER appears to play a role in regulating both vessel density and cardiac development PMID: 23200275
    7. BMPER expression is decreased following lung injury, which in turn impairs epithelial integrity, characterized by reduction of E-cadherin and epithelial leakage in vitro and in vivo. PMID: 23716395
    8. Bmper is a critical regulator of Bmp-mediated vascular inflammation and that the fine-tuning of Bmp and Bmper levels is essential in the maintenance of normal vascular homeostasis. PMID: 22772758
    9. The data unequivocally demonstrated that BMPER is highly expressed in malignant tumors and that the growth of lung, colon, and uterine carcinomas is dependent on the presence of BMPER. PMID: 22020334
    10. Bmper may play an important role in suppressing hepcidin production in hypotransferrinemic mice. PMID: 22144676
    11. BMP modulator BMPER is a new protective regulator of vascular inflammation that modulates leukocyte adhesion and migration in vitro and in vivo. PMID: 21900199
    12. BMPER is important in the regulation of BMP signaling and revascularization in the hypoxic retina. PMID: 21737784
    13. The data indicate a role for CV2 and Chd in the establishment of the vertebral morphogenetic field through the long-range relocalization of Chd/BMP complexes. PMID: 20807528
    14. Cv2 enhances pro-BMP activity of Tsg. PMID: 19914233
    15. Cv2 is a conserved, positive regulator of bone morphogenetic protein signaling. Its cysteine-rich domains acts as both positive and negative modulators of BMP signaling. PMID: 15188429
    16. crossveinless 2 has essential pro-Bmp functions for locally restricted signal enhancement in multiple aspects of mammalian organogenesis. PMID: 17035289
    17. The context-dependent functional relationship between Tsg and Cv2 during mouse development, is presented. PMID: 18644438
    18. Cv2 may specify cardiac mesodermal lineage through inhibition of BMP signaling at early stage of cardiogenesis. PMID: 18662983
    19. Development of the vertebral morphogenetic field is reported in the interactions of CV-2 and Twg. PMID: 18789316
    20. Study demonstrates that as molar concentrations of Bmper exceed Bmp4, Bmper dynamically switches from an activator to an inhibitor of Bmp4 signaling. PMID: 19221194

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  • 亞細胞定位：
    Secreted.
  • 數(shù)據(jù)庫鏈接：


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